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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC6A4
All Species:
1.21
Human Site:
T66
Identified Species:
2.42
UniProt:
P31645
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31645
NP_001036.1
630
70325
T66
T
R
H
S
I
P
A
T
T
T
T
L
V
A
E
Chimpanzee
Pan troglodytes
XP_001135066
630
70262
A66
T
R
H
S
I
P
A
A
T
T
T
L
V
A
E
Rhesus Macaque
Macaca mulatta
Q9MYX0
630
70239
A66
T
R
H
S
I
P
A
A
T
T
T
L
V
A
E
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q60857
630
70129
A66
A
P
H
S
T
P
A
A
T
T
T
L
V
A
E
Rat
Rattus norvegicus
P31652
630
70153
A66
A
S
H
S
I
P
A
A
T
T
T
L
V
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508462
865
94609
P296
G
V
R
C
V
L
A
P
Q
G
G
D
P
H
L
Chicken
Gallus gallus
NP_998737
670
74409
G106
T
T
T
S
T
T
C
G
A
E
G
Q
Q
Q
L
Frog
Xenopus laevis
A7Y2W8
633
71004
F76
I
F
C
G
I
P
L
F
F
M
E
L
S
F
G
Zebra Danio
Brachydanio rerio
NP_001035061
646
72103
T79
N
T
P
G
T
F
R
T
L
V
V
Q
Q
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P51905
622
69307
N61
L
A
P
K
L
A
N
N
E
R
I
L
V
V
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q03614
615
69247
W64
A
V
D
L
G
N
I
W
R
F
P
Y
L
C
F
Sea Urchin
Strong. purpuratus
XP_001204030
641
70931
Y75
N
G
D
N
R
I
T
Y
D
T
N
E
P
R
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.5
N.A.
N.A.
92.8
91.7
N.A.
38.1
77.6
42.1
68.5
N.A.
50.4
N.A.
43.6
49.4
Protein Similarity:
100
99.5
99.5
N.A.
N.A.
95.5
94.9
N.A.
52.9
85.2
60.8
80.6
N.A.
66.9
N.A.
63.3
66.6
P-Site Identity:
100
93.3
93.3
N.A.
N.A.
73.3
80
N.A.
6.6
13.3
20
6.6
N.A.
13.3
N.A.
0
6.6
P-Site Similarity:
100
93.3
93.3
N.A.
N.A.
73.3
80
N.A.
13.3
13.3
20
6.6
N.A.
20
N.A.
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
25
9
0
0
0
9
50
34
9
0
0
0
0
42
0
% A
% Cys:
0
0
9
9
0
0
9
0
0
0
0
0
0
9
0
% C
% Asp:
0
0
17
0
0
0
0
0
9
0
0
9
0
0
9
% D
% Glu:
0
0
0
0
0
0
0
0
9
9
9
9
0
0
42
% E
% Phe:
0
9
0
0
0
9
0
9
9
9
0
0
0
9
9
% F
% Gly:
9
9
0
17
9
0
0
9
0
9
17
0
0
0
9
% G
% His:
0
0
42
0
0
0
0
0
0
0
0
0
0
9
0
% H
% Ile:
9
0
0
0
42
9
9
0
0
0
9
0
0
0
0
% I
% Lys:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
9
0
0
9
9
9
9
0
9
0
0
59
9
0
17
% L
% Met:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% M
% Asn:
17
0
0
9
0
9
9
9
0
0
9
0
0
0
0
% N
% Pro:
0
9
17
0
0
50
0
9
0
0
9
0
17
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
9
0
0
17
17
9
0
% Q
% Arg:
0
25
9
0
9
0
9
0
9
9
0
0
0
9
0
% R
% Ser:
0
9
0
50
0
0
0
0
0
0
0
0
9
0
17
% S
% Thr:
34
17
9
0
25
9
9
17
42
50
42
0
0
9
0
% T
% Val:
0
17
0
0
9
0
0
0
0
9
9
0
50
9
0
% V
% Trp:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
9
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _